Warframe: How To Get Nidus/Nidus Prime (2026) Guide

Nidus is a Warframe that is one with the infestation, having adapted to it and now using this mutation to destroy his enemies when on the field of battle.

Unlike most Warframes, Nidus has no shields and lives purely with health and a high amount of armor, perfect to match builds that can convert damage into energy.

Nidus makes use of his mutations to deal damage to his enemies or heal his team while also disabling his foes or empowering his allies on the battlefield.

How To Get Nidus?

You may obtain the Nidus main blueprint by completing The Glast Gambit quest, while his other parts are farmed by doing Infested Salvages.

How To Get Nidus Blueprint?

A quest called The Glast Gambit is available in your Codex once you have completed The War Within¸, which pits you against Nef Anyo’s treachery against the Mycona Colony.

During the quest, you will be participating in The Index multiple times until things take a huge turn, and you will need to go out of your way to save a child named Neewa.

If you happen to need another Main Blueprint for Nidus, you can purchase it from Cephalon Simaris at the cost of 50,000 standing.

How To Get Nidus Parts?

You can obtain Nidus components as rewards for completing rotations during the Infested Salvage mission, which is Oestrus on Eris.

All parts may be obtained on Rotation C with a 14.29% chance to obtain the Nidus Chassis Blueprint, Nidus Neuroptics Blueprint, or the Nidus Systems Blueprint.

Nidus Crafting Requirements

Nidus Main Blueprint

• 25,000 Credits
• 1 Nidus Neuroptics
• 1 Nidus Chassis
• 1 Nidus Systems
• 2,000 Kuva

Nidus Neuroptics

• 15,000 Credits
• 10 Mutagen Sample
• 1,000 Plastids
• 2,600 Polymer Bundle
• 3 Neural Sensors

Nidus Chassis

• 15,000 Credits
• 6,000 Polymer Bundle
• 1,400 Plastids
• 5,000 Nano Spores
• 3 Neurodes

Nidus Systems

• 15,000 Credits
• 6,000 Nano Spores
• 3,5000 Circuit
• 14 Morphics
• 6 Orokin Cell

How To Get Nidus Prime?

Nidus Prime is an upgraded version of Nidus that features a higher amount of Health, Armor, and Energy, which makes him more durable.

Stat Comparison

Nidus Prime Void Relics

Nidus Prime Crafting Requirements

Nidus Main Blueprint

• 25,000 Credits
• 1 Nidus Neuroptics
• 1 Nidus Chassis
• 1 Nidus Systems
• 2,000 Kuva

Nidus Neuroptics

• 15,000 Credits
• 10 Mutagen Sample
• 1,000 Plastids
• 2,600 Polymer Bundle
• 3 Neural Sensors

Nidus Chassis

• 15,000 Credits
• 6,000 Polymer Bundle
• 1,400 Plastids
• 5,000 Nano Spores
• 3 Neurodes

Nidus Systems

• 15,000 Credits
• 6,000 Nano Spores
• 3,5000 Circuit
• 14 Morphics
• 6 Orokin Cell

Nidus Abilities

Passive Abilities

• Mutation Stacks

Nidus gains mutation stacks when you hit an enemy with Virulence, when maggots from Ravenous explode on enemies, or when enemies caught by Larva die.

The Mutation Stacks increase the damage dealt by Virulence and the maggot explosions from the Ravenous ability.

Mutation Stacks are needed to cast Parasitic Link (1 Stack) or to cast Ravenous (3 Stacks)

• Undying

When Nidus is just about to die, his Undying passive ability will be activated as long as he has at least 15 Mutation Stacks, preventing him from dying.

Undying will temporarily make him invulnerable, giving you the chance to fight back or escape while it is active.

1) Virulence

Nidus stomps on the ground with tremendous force, causing it to rupture and unleashing fungal growth that damages enemies and steals energy.

Each time an enemy is hit, 1/5 mutation stacks are granted, which provides you with 1 stack if you hit 5 enemies.

Virulence (Max Rank)

Augment Mods: Teeming Virulence provides Nidus with a buff that increases his Primary Weapon Critical Hit Chance when 4 or more enemies have been hit with a single cast. Obtained from The Perrin Sequence/Steel Meridian.

2) Larva

Nidus sends out an infested pod that erupts with tendrils that latch onto enemies and pull them towards the pod.

Enemies will be held in the pod for a specific period until the duration is over, dropping the enemies to the ground.

Larva (Max Rank)

Augment Mods: Larva Burst provides you with the ability to force detonate the pod, dealing damage to all enemies within range of it. Obtained from The Perrin Sequence/Steel Meridian.

To know more about Nidus effective builds read our below guide:

Warframe Nidus Build 2025 Guide

3) Parasitic Link

Binding himself to an ally or enemy, Nidus can use Parasitic Link to either buff the damage and Ability Strength of an ally or divert damage to an enemy.

Nidus can use this ability on an enemy to avoid taking damage, and once released, the enemy will take the reflected damage.

Parasitic Link Stats (Max Rank)

Augment Mods: Parasitic Vitality provides 4% Max Health per Mutation to both Nidus and an ally that he is linked to for the duration of Parasitic Link. Obtained from The Perrin Sequence/Steel Meridian.

4) Ravenous

Releasing the infestation within, Nidus causes the ground around him to burst to spread maggots and causing the area to become infested.

Maggots will spawn and attack enemies until they explode, dealing damage in an area around them, which can also be forced by hitting them with Virulence.

Nidus and his allies will regenerate health while they are in the affected area, providing more survivability for the team.

Ravenous (Max Rank)

Augment Mods: Insatiable is a Ravenous Augment that provides Nidus with a chance to gain an additional Mutation Stack when he obtains one while in a Ravenous infestation. Obtained from The Perrin Sequence/Steel Meridian.

Verdict

Nidus is one of the more different Warframes that was released, combining both Warframe and infestation to create a powerful entity.

With the right technique of making, it is a habit of using Larva followed by Virulence to get a lot of stacks as soon as possible, Nidus can become seemingly unstoppable.

This Warframe provides both good offense with damage dealt from his abilities as well as defense with his healing and crowd control.